Buy Methylone Online
3,4-Methylenedioxymethcathinone (Methylone) [“Bath salt,” bk-MDMA, MDMC, MDMCAT, “Explosion,” “Ease,” “Molly”] December 2019
Introduction:
3,4-Methylenedioxymethcathinone (methylone) is a designer drug of the phenethylamine class. Methylone is a synthetic cathinone with substantial chemical, structural, and pharmacological similarities to 3,4-methylenedioxymethamphetamine
3,4-Methylenedioxymethcathinone (methylone) is a designer drug of the phenethylamine class. Methylone is a synthetic cathinone with substantial chemical, structural, and pharmacological similarities to 3,4-methylenedioxymethamphetamine
Methylone
Molecular Formula C11H13NO3
Molecular Formula C11H13NO3
The core chemical structure of methylone identifies it as a phenethylamine, and it is related in chemical structure to MDMA differing only by an oxygen atom on the phenethylamine side chain. Methylone is a solid at room
temperature. The Chemical Abstract Service (CAS) number is 186028-79-5 and the Chemical Abstract index name is 1-(1,3-benzodioxol-5-yl)-2-(methylamino)-1-propanone.
temperature. The Chemical Abstract Service (CAS) number is 186028-79-5 and the Chemical Abstract index name is 1-(1,3-benzodioxol-5-yl)-2-(methylamino)-1-propanone.
Pharmacology:
There are substantial pharmacological similarities between methylone and MDMA. Methylone and MDMA, similar to cocaine and methamphetamine, inhibit in vitro the neuronal reuptake of the monoamines dopamine and serotonin and increase concentrations of these monoamines in the synaptic cleft. Similar to methamphetamine, methylone and MDMA also increase, in vitro, the neuronal release of these monoamines.
There are substantial pharmacological similarities between methylone and MDMA. Methylone and MDMA, similar to cocaine and methamphetamine, inhibit in vitro the neuronal reuptake of the monoamines dopamine and serotonin and increase concentrations of these monoamines in the synaptic cleft. Similar to methamphetamine, methylone and MDMA also increase, in vitro, the neuronal release of these monoamines.
An increase in monoamine concentrations in the central nervous system is thought to be
involved in the pharmacological effects of these substances. Methylone also resembles MDMA in drug discrimination assays. Methylone fully substitutes (>80%) for MDMA in rats trained to discriminate MDMA from saline. Methylone (ED50=6.9 μmol/kg) was about half as potent as MDMA (ED50=3.5 μmol/kg) in these studies. In rats trained to
discriminate (+)-amphetamine from saline, both methylone (ED50=10.1 μmol/kg) and MDMA (ED50=7.5 μmol/kg) completely (>80%) substituted for amphetamine with similar potencies. Furthermore, methylone, similar to MDMA, does not substitute for 4-methyl-2,5-dimethoxyamphetamine (DOM), a schedule I hallucinogen, in rats trained to discriminate DOM from saline.
involved in the pharmacological effects of these substances. Methylone also resembles MDMA in drug discrimination assays. Methylone fully substitutes (>80%) for MDMA in rats trained to discriminate MDMA from saline. Methylone (ED50=6.9 μmol/kg) was about half as potent as MDMA (ED50=3.5 μmol/kg) in these studies. In rats trained to
discriminate (+)-amphetamine from saline, both methylone (ED50=10.1 μmol/kg) and MDMA (ED50=7.5 μmol/kg) completely (>80%) substituted for amphetamine with similar potencies. Furthermore, methylone, similar to MDMA, does not substitute for 4-methyl-2,5-dimethoxyamphetamine (DOM), a schedule I hallucinogen, in rats trained to discriminate DOM from saline.
Because of the structural and pharmacological similarities between methylone and MDMA, the psychoactive effects, adverse health risks, and signs of intoxication resulting from methylone abuse are likely to be similar to those of MDMA. Several chat rooms discussed pleasant and positive effects of methylone when used for recreational purpose.
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User Population:
Methylone, like other synthetic cathinones, is a recreational drug that emerged on the United States’ illicit drug market in 2009. It is perceived as being a ‘legal’ alternative to drugs of abuse like MDMA, methamphetamine, and cocaine. Evidence indicates that youths and young adults are the primary users of synthetic cathinone substances which include methylone. However, older adults also have been identified as users of these
substances.
substances.
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